These studies suggest a vascular site of action for indapamide and a mode of action different from that of hydrochlorothiazide. Indapamide is a derivative of benzolsulfonamide and its mechanism of action is analogous to that of thiazides. This effect may result from direct arteriolar vasodilatation through. This same effect may cause hypokalcemia in susceptible individuals. Indapamide should be used with caution in patients with renal impairment as it may induce azotemia in patients with severe renal insufficiency. Mechanisms for blood pressure lowering and metabolic effects of. The drug enhances the excretion of sodium, chloride, and water by inhibiting the transport of sodium ions across the renal tubule. Webmd provides common contraindications for indapamide oral.
Indapamide lozol is a new diuretic and antihypertensive agent. Telmisartan is an angiotensin ii receptor blocker that shows high affinity for the angiotensin ii receptor type 1 at 1, with a binding affinity 3000 times greater for at 1 than at 2. The hypovolemic action of indapamide is believed to be. Indapamide is a 2methyl indoline derivative of 4chloro3sulfamoyl benzamide. Pdf complementary mechanisms of action and rationale for.
The mechanism for the antihypertensive effects of thiazides is poorly understood. The related drug information index provides comprehensive access to all drug information related to a specific drug types of content include full prescribing information, drug summaries, full prescribing information continuing medication education full pi cme, medication guides, risk evaluation and mitigation strategies rems summaries, rems continuing medication education rems cme, and. Indapamide appears to cause vasodilation, probably by inhibiting the passage of calcium and other ions sodium, potassium across membranes. The mechanism whereby indapamide exerts its action in the control of hypertension is not completely elucidated. Mental status monitoring is recommended in patients with liver impairment.
Only select registry of toxic effects of chemical substances rtecs data is presented here. Indapamide oral tablet is a prescription medication thats used to treat high blood pressure, as well as edema in people with congestive heart failure. Thiazide and thiazidelike diuretics act on the nephron mainly at the proximal part of the distal tubule. Indapamide investigated as a drug and reproductive effector. Indapamide side effects, dosage, interactions drugs. Summary indapamide is an effective antihypertensive agent for which a dual mechanism of action has been put forward. Indapamide 1 is an orally active sulphonamide diuretic agent. Indapamide blocks the slow component of delayed rectifier potassium current iks without altering the rapid component ikr or the inward rectifier current. In limited controlled trials that compared the effect of indapamide combined with other. Plasma elimination half life is biphasic and between 14 and 25 hours. Complementary mechanisms of action and rationale for the. Indapamide reference guide for safe and effective use from the american. Action mechanism is similar to that of the thiazide diuretics.
Increases sodium and water excretion by inhibiting sodium reabsorption in distal tubule. Mechanism of action of indapamide it exerts thiazides like diuretic action by acting at site3central dilating segment of early distal tubule. Are sulfonamide derivatives ethacrynic acid is a phenoxyacetic acid derivative site of action. The steadystate concentration of indapamide is reached within 3 to 4 days when chronically administered. Lozol may add to or potentiate the action of other antihypertensive drugs. The drug appears to have a unique mechanism of action, combining diuretic. Looking for online definition of indapamide in the medical dictionary. Find patient medical information for indapamide oral on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. The renal site of action is the proximal part of the distal tubule and the ascending part of henles loop. Advance compared the use of a fixed combination of perindoprilindapamide to placebo in over 11,000 patients with type 2 diabetes.
Find out what health conditions may be a health risk when taken with indapamide oral. The mechanism whereby lozide exerts its action in the control of hypertension is not completely elucidated. Indapamide is bound to plasma proteins in 79% and has a relatively low apparent volume of distribution of approximately 60 l. The renal site of action is the proximal part of the distal tubule and the ascending part of. Indapamide definition of indapamide by medical dictionary. Indapamide increases urinary excretion of sodium and water by inhibiting sodium reabsorption in the cortical diluting tubule of the nephron, thus relieving edema. Indapamide is an indole derivative of chlorosulphonamide and a sulfamyl diuretic with antihypertensive activity. The mechanism of the antihypertensive action of indapamide has not been definitively established, but may be related to relaxation of vascular smooth muscle. Summary indapamid is an effective antihypertensive e agen fot r which a dual mechanism of action.
Complementary mechanisms of action and rationale for the fixed combination of perindopril and indapamide in treating hypertension update on clinical utility. Enhances excretion of sodium, potassium, and water by interfering with sodium transfer across renal epithelium of the tubules. Indapamide has also been shown to cause uterine myometrial relaxation in experimental animals. S summary indapamid is an effective antihypertensive e agen fot r which a dual mechanism of action has been put forward.
Hypersensitivity to indapamide or other sulfonamide derivatives, anuria. Principal site of action is on the proximal portion of the distal renal tubules. The drug appears to have a unique mechanism of action, combining diuretic effects with a direct vascular action, presumably secondary to calcium channel blockade. In order to understand the mechanism responsible for the sustained antihyper tensive effect of indapamide, hicks analyzed vascular responsiveness in hyperten sive rats pretreated with the drug 30. Although the mechanism of action is not clear, indapamide appears to act principally on the distal convoluted tubules of the nephron.
Coversyl plus is a combination of perindopril arginine, an angiotensin converting enzyme ace inhibitor, and indapamide, a chlorosulphamoyl diuretic, in which the doses of the ace inhibitor and diuretic components are lower than the usual doses used for monotherapy. Cardiovascular studies show small increases in cardiac output, heart rate and stroke volume with a significant reduction in. See what others have said about indapamide, including the effectiveness, ease of use and side effects. In limited controlled trials that compared the effect of indapamide combined with other antihypertensive drugs with the effect of the other drugs administered alone, there was no notable change in the nature or frequency of adverse reactions associated with the. If adequate bp response not achieved with a single antihypertensive agent, either increase dosage of single drug or add a second drug with demonstrated benefit and preferably a complementary mechanism of action e. It is also thought to have effects on vascular smooth muscle by decreasing inward calcium currents and.
Indapamide about indapamide thiaziderelateda nonthiazide sulphonamide drug, diuretic, antihypertensive. Specifically it blocks or antagonizes the action the proteins kcnq1 and kcne1. Review side effects, drug interactions, and dosage information prior to taking this medication. Pharmacology figure 1 outlines the pharmacological action of indapamide. It is intended for lowering arterial blood pressure and as an adjuvant drug for treating edema caused by cardiac insufficiency. Indapamide may add to or potentiate the action of other antihypertensive drugs. Indapamide diuresis may induce hepatic encephalopathy in some patients with severe liver disease. Pharmacology and clinical use of diuretics katie herndon, pharm. Indapamide blocks the slow component of delayed rectifier potassium current iks without altering the rapid component. Which thiazide to choose as addon therapy for hypertension.
Indapamide mechanism of action thiazide and thiazidelike diuretics act on the nephron mainly at the proximal part of the distal tubule. The thiazidelike diuretics indapamide and chlorthalidone are more effective than the thiazidetype diuretics including hydrochlorothiazide for reducing the risk of heart attack, stroke, and heart failure in persons with high blood pressure and the thiazidelike and thiazidetype diuretics have similar rates of adverse effects. It is referred to as a thiazidelike diuretic as it lacks the benzothiadiazine heterocycle seen with the thiazide group of drugs, although it retains a sulphonamide moiety. Indapamide is a prescription medicine used to treat high blood pressure its also given to people who suffer from edema fluid retention due to congestive heart disease or another medical. Exact mechanism of antihypertensive effect of indapamide is unknown. It is not clear whether indapamide reduces blood pressure by a vasodilator or a diuretic action. Indapamide is a nonthiazide sulphonamide with an indole ring, belonging to the diuretic family. Indapamide lozol discontinued is a medication prescribed for the treatment of high blood pressure and edema that may result from congestive heart failure. The molecular mecha nism of action is similar to the thiazide.
1025 1161 728 232 848 321 1137 914 1022 593 1044 466 628 1223 971 1478 1351 712 142 522 728 644 1499 914 1290 543 340